- Week 1 will feature four prime-time games between Thursday and Monday.
 - The playoff rematch between Buffalo and Baltimore on Sunday night looms as the game of the weekend.
 - One of our experts picked nearly 73% of the games correctly in 2024.
 
Since the Philadelphia Eagles won Super Bowl 59 in February, a full 207 days have passed ahead of their 2025 regular-season kickoff opener against the Dallas Cowboys on Thursday night. In between? There was a draft, free agency, Micah Parsons got traded from the Cowboys, Taylor Swift and Travis Kelce got engaged, Nike rolled out some slick new uniforms … but no legit NFL football.
But now our cups runneth over. Following Eagles-Cowboys, the Week 1 smorgasbord rolls onward Friday night, when Kelce’s Kansas City Chiefs face the Los Angeles Chargers in São Paulo, and Swift will reportedly be in attendance at Corinthians Arena.
Sunday’s 13-game stack kicks off with Pittsburgh Steelers QB Aaron Rodgers’ return to ‘JetLife’ Stadium and ends with a playoff rematch between former MVP Lamar Jackson’s Baltimore Ravens and reigning MVP Josh Allen’s Buffalo Bills.
Week 1 ends Monday night in Chicago, where the new-look Bears will host the Minnesota Vikings in QB J.J. McCarthy’s first regular-season start.
Can’t. Wait.
(But to tide you over in the interim, Week 1 picks from USA TODAY Sports’ panel of NFL experts.)
(Odds provided by BetMGM)
- Dallas Cowboys at Philadelphia Eagles
 - Kansas City Chiefs at Los Angeles Chargers
 - New York Giants at Washington Commanders
 - Tampa Bay Buccaneers at Atlanta Falcons
 - Las Vegas Raiders at New England Patriots
 - Arizona Cardinals at New Orleans Saints
 - Pittsburgh Steelers at New York Jets
 - Miami Dolphins at Indianapolis Colts
 - Cincinnati Bengals at Cleveland Browns
 - Carolina Panthers at Jacksonville Jaguars
 - San Francisco 49ers at Seattle Seahawks
 - Tennessee Titans at Denver Broncos
 - Detroit Lions at Green Bay Packers
 - Houston Texans at Los Angeles Rams
 - Baltimore Ravens at Buffalo Bills
 - Minnesota Vikings at Chicago Bears
 
                        